Vaccine Trials for the Clinician: Prospects for Viral and Non‐Viral Vectors
نویسندگان
چکیده
منابع مشابه
Vaccine Trials for the Clinician: Prospects for Viral and Non-Viral Vectors.
Recent progress in tumor genetics, tumor biology, and tumor immunology has renewed interest in the development of tumor vaccines. Unlike the previous generation of vaccines that consisted of the patient's own tumor cells in some form, the new vaccines contain defined peptides or genes with a known function. In order to induce a potent and long-lasting cell-mediated antitumor response, viral as ...
متن کاملVaccine Trials for the Clinician: Prospects for Tumor Antigens.
Recent insights in antigen presentation, the identification of human tumor antigens, and the demonstration of MHC class-I-restricted cytotoxic T lymphocyte (CTL) recognition of peptides encoded by tumor antigen have renewed the interest and enthusiasm for the development of cancer vaccines. Melanoma serves as a paradigm of an immunogenic human tumor, and several tumor antigens, including MAGE, ...
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15 صفحه اولViral vectors for vaccine applications
Traditional approach of inactivated or live-attenuated vaccine immunization has resulted in impressive success in the reduction and control of infectious disease outbreaks. However, many pathogens remain less amenable to deal with the traditional vaccine strategies, and more appropriate vaccine strategy is in need. Recent discoveries that led to increased understanding of viral molecular biolog...
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Recombinant vectors can be used to deliver antigens and to stimulate immune responses in humans. Viral vectors possess various intrinsic properties which may lend to advantages and disadvantages for usage for a given therapeutic application [reviewed by Larocca and Schlom] [1]. The safety and flexibility of recombinant viral vectors have lead to their usage in gene therapy, virotherapy, and vac...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 1997
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2-5-300